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IntroductionA slide enables you you to conveniently store a large number of different 3D visualization properties (e.g. color, viewpoint, representation etc...) along with text and window layout. ActiveICM enables you to view and display ICM graphical slides and animations interactively inside Windows Microsoft PowerPoint and web browsers such as Internet Exporler and Mozilla Firefox.In this example we are going to look at the effect of an agonist binding to the Beta-2-Adrenergic GPCR (B2AR) and prepare a molecular document. A prepared ICM file containing three B2AR GPCRs superimposed can be downloaded here ftp://ftp.molsoft.com/pub/workshop/ (1. cut and paste the address into a web browser. 2. Right click on GPCR_slides.icb and choose "Save Link As". 3. Open the .icb in ICM File/Open). The file contains pdb files 2RH1 (R inactive state), 3P0G (R* active state, with G-alpha mimic), and 3SN6 (R*G G-protein signalling state). The agonist ligand causes Helix 5 to shift inwards and Helix 6 to swing outwards. This agonist binding poses were predicted using ICM a year before the crystal structures were solved, you can read about this here and a good review of the structure and function of GPCRs here.
TutorialIn this tutorial we will build a series of slides and then annotate them using HTML to create hyperlinks to the slides. The resulting molecular document can be exported in movie format or in fully interactive 3D files.
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