Quick_Facts

GYG1A: Human Glycogenin-1

Chaikuad, A., Froese, D.S., Yue, W. W., Krysztofinska, E., von Delft, F., Lee, W.H., Marsden, B.D., Liu. Q., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Oppermann, O.

3Q4S (deposited on 24.Dec.2010)
3QVB (deposited on 24.Dec.2010)
3RMW (deposited on 21.Apr.2011)
3RMV (deposited on 21.Apr.2011)
3T7M (deposited on 30.Jul.2011)
3T7N (deposited on 30.Jul.2011)
3T7O (deposited on 30.Jul.2011)

Datapack version: 2 (built on 23.May.2011; last revised on 08.Sep.2011)

Quick Facts

SGC target ID

GYG1A

QUICK FACTS

Human glycogenin 1

Updated

2011-05-24

Domain architecture of solved Structure (Pfam)

Protein Mass

39.384 kDa

Number of residues

350 aa

Contact info.

Gene ID

GYG1

Genecard

GYG1

cDNA source

Gene sequence

NM_004130.2

Protein sequence

NP_004121.2

Biochemical function

Unclassified

Biological function

  • Metabolism
  • Energy pathways

Human mutations

OMIM: 603942

Mouse models

Summary role in disease

Closest sequence matches of solved domain(s) (10 or less)

Name

ID%

Description

NP_004121.2

100.

glycogenin-1 isoform 1 [Homo sapiens]

NP_001171649.1

100.

glycogenin-1 isoform 2 [Homo sapiens]

gi|34783423

100.

GYG1 protein [Homo sapiens]

gi|119599303

100.

glycogenin 1, isoform CRA_c [Homo sapiens]

gi|189055328

99.71

unnamed protein product [Homo sapiens]

XP_003310161.1

99.42

PREDICTED: glycogenin-1 isoform 1 [Pan troglodytes]

XP_516810.3

99.39

PREDICTED: glycogenin-1 isoform 3 [Pan troglodytes]

gi|322812775

99.23

Chain A, Crystal Structure Of Human Glycogenin-1 (Gyg1), Apo Form

gi|332639932

99.23

Chain A, Crystal Structure Of Human Glycogenin-1 (Gyg1) T83m Mutant Complexed With Manganese And Udp-Glucose

gi|67971052

99.09

unnamed protein product [Macaca fascicularis]

Closest match in PDB (solved domain(s))

Name

ID%

ICM-pP

Description

1LL2

89.78

59.24

Chain A, Crystal Structure Of Rabbit Muscle Glycogenin Complexed With Udp-Glucose And Manganese

1LL0

88.20

58.61

Chain A, Crystal Structure Of Rabbit Muscle Glycogenin

1ZCU

85.14

57.30

Chain A, Apo Form Of The 162s Mutant Of Glycogenin

1ZCV

85.14

57.37

Chain A, Apo Form Of A Mutant Of Glycogenin In Which Asp159 Is Replaced By Asn

1ZCY

85.14

57.30

Chain A, Apo Form Of A Mutant Of Glycogenin In Which Asp159 Is Replaced By Ser

1ZCT

83.79

52.68

Chain A, Structure Of Glycogenin Truncated At Residue 270 In A Complex With Udp

Splice forms

ENSG00000163754

ProSite hits

localization

Protein expression

  • Skeletal muscle
  • Heart
  • Brain
  • Placenta
  • Lung
  • Liver
  • Kidney
  • Pancreas
  • Leukocyte

Substrates/ cofactors/ inhibitors

Interacting proteins

  • GNIP
  • Glycogen synthase 1
  • Glycogenin 1
  • Glycogenin 2
  • Nuclear envelope pore membrane protein POM 121

Link to HPRD website

Posttranslational modifications

Link to HPRD website

Key references

PubMed: 15860684, 15870102, 17311895.

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