This tool will identify cavities within a molecule which are completely closed,. If you are looking for buried and open pockets then use icmPocketFinder.

• Read in a protein structure (File/Open or PDB Search)
• Tools/Analysis/Closed Cavities
• Use the drop down arrow to locate the receptor you are interested in.
• Enter the minimum volume of the cavities you wish to identify.
• Click OK
• The closed cavities will be displayed in the meshes section of the ICM Workspace and a table of the cavities will be displayed. Double click on a row in the table to jump to a particular closed cavity and select the residues surrounding it.